Title

The frequency and functional impact of overlapping hypertension on hypertrophic cardiomyopathy: A single-center experience

Document Type

Article

Publication Title

Journal of Clinical Hypertension

Abstract

Between 1995 and 2005, 196 adults with hypertrophic cardiomyopathy (HCM) were evaluated. Among these, 122 (62%, group 1) patients also had systemic hypertension. The clinical presentation, management, outcome, and echocardiographic findings of these patients were compared with 74 (38%, group 2) patients without systemic hypertension. Patients in group 1 were older at the time of HCM diagnosis and had a higher prevalence of diabetes (28% vs 9%; P=02) and coronary artery disease (40% vs 25%; P=03). In addition, echocardiography showed a significantly higher prevalence of systolic anterior motion of the anterior mitral valve in association with dynamic left ventricular outflow obstruction (52% vs 19%; P=02) and mitral annular calcification (27% vs 13%; P=03) in group 1 patients. Left ventricular wall thickness (17 mm vs 19 mm), end-diastolic diameter (42 mm vs 42 mm), resting outflow tract gradient >30 mm Hg (17% vs 16%), and ejection fraction (65% vs 64%) were similar in the two groups. HCM frequently coexists with systemic hypertension in the adult population. Presence of systemic hypertension in HCM patients is associated with older age and higher risk of diabetes, coronary artery disease, and noncardiac death. © 2010 Wiley Periodicals, Inc.

First Page

240

Last Page

245

DOI

10.1111/j.1751-7176.2009.00251.x

Publication Date

4-1-2010

This document is currently not available here.

Share

COinS