BRASH Syndrome: A Rare Clinical Phenomenon

Authors

Nicholas Roma, Department of Internal Medicine, St. Luke’s University Health Network, Bethlehem, Pennsylvania, USA
Vikram Padala, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA
Megan Pattoli, Department of Internal Medicine, St. Luke’s University Health Network, Bethlehem, Pennsylvania, USA
Spandan Desai, Department of Internal Medicine, St. Luke’s University Health Network, Bethlehem, Pennsylvania, USA
Matthew Krinock, Department of Cardiology, St. Luke’s University Health Network, Bethlehem, Pennsylvania, USA
Matthew Durkin, Department of Cardiology, St. Luke’s University Health Network, Bethlehem, Pennsylvania, USA
Patrick Field, Department of Cardiology, St. Luke’s University Health Network, Bethlehem, Pennsylvania, USA
Tarick Sheikh, Department of Cardiology, St. Luke’s University Health Network, Bethlehem, Pennsylvania, USA

Document Type

Article

Abstract

Bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia (BRASH) syndrome is a rare medical phenomenon, with only approximately 70 reported cases, carrying a mortality of 5.7%.1,2 Presentation is variable, but it can range from asymptomatic bradycardia to multisystem organ failure.3 The unique pathophysiology of BRASH syndrome involves synergy between atrioventricular nodal blocking agents and hyperkalemia, leading to severe bradycardia and renal malperfusion. Here, we present a case of a 66-year-old female patient who was found to fit the clinical picture of BRASH syndrome, in whom the prompt diagnosis and intervention led to a positive outcome.

First Page

840

Last Page

842

DOI

10.1016/j.cjco.2024.03.013

Publication Date

4-2-2024

Recommended Citation

Roma N, Padala V, Pattoli M, Desai S, Krinock M, Durkin M, Field P, Sheikh T. Brash syndrome: a rare clinical phenomenon. CJC open. 2024 Apr 2;6(6):840.