Title

Efficacy and Safety of Whole Blood Transfusion in Non-Trauma Patients

Authors

Alison A. Smith, Department of Surgery, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Rahaf Alkhateb, Department of Pathology, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Maxwell Braverman, Department of Surgery, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Charles P. Shahan, Department of Surgery, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Benjamin Axtman, Department of Surgery, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Susannah Nicholson, Department of Surgery, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Leslie Greebon, Department of Pathology, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Brian Eastridge, Department of Surgery, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Rachelle B. Jonas, Department of Surgery, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Ronald Stewart, Department of Surgery, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Randi Schaefer, Southwest Texas Regional Advisory Council, San Antonio, TX, USA.
Mark Foster, Department of Surgery, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Donald Jenkins, Department of Surgery, 14742University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Document Type

Article

Publication Title

The American surgeon

Abstract

Whole blood (WB) transfusion for trauma patients with severe hemorrhage has demonstrated early successful outcomes compared to conventional component therapy. The objective of this study was to demonstrate WB transfusion in the non-trauma patient. Consecutive adult patients receiving WB transfusion at a single academic institution were reviewed from February 2018 to January 2020. Outcomes measured were mortality and transfusion-related reactions. A total of 237 patients who received WB were identified with 55 (23.2%) non-trauma patients. Eight patients (14.5%) received pre-hospital WB. The most common etiology of non-traumatic hemorrhage was gastrointestinal bleeding (43.6%, n = 24/55). Approximately half of the non-trauma patients (n = 28/55) received component therapy. Transfusion-related events occurred in 3 patients. This study demonstrated that non-trauma patients could receive WB transfusions safely with infrequent transfusion-related events. Future studies should focus on determining if outcomes are improved in non-trauma patients who receive WB transfusions and defining specific transfusion criteria for this population.

First Page

31348211048831

DOI

10.1177/00031348211048831

Publication Date

9-30-2021

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