The Psoriasis Mortality Paradox in Acute Myocardial Infarction: A Nationwide Inpatient Sample Analysis
Document Type
Article
Abstract
Background: Psoriasis is associated with increased cardiovascular risk. There is conflicting data about outcomes in acute myocardial infarction (AMI) patients with and without psoriasis.
Methods: National Inpatient Sample 2016-2019 was used to identify AMI patients with and without psoriasis. Analysis was done using logistic regression.
Results: We identified 2.55 million in-hospital AMI patients in the 4-year period 2016 to 2019, of which 15,520 patients had psoriasis. At baseline (Table 1), psoriasis patients had significantly higher rates of smoking (31% vs 25%), alcohol use (1.39% vs 1%), diabetes (43% vs 41%), hypertension (47% vs 44%), dyslipidemia (71% vs 66%), prior coronary artery disease (83% vs 80%), COPD (25% vs 22%) and thyroid disease (14% vs 13%). Psoriasis patients had significantly lower age (64.9 vs 66.9 years), congestive heart failure (38% vs 42%), and chronic kidney disease (19% vs 22%). Psoriasis patients had similar rates of stent placement (28%) but significantly higher rates of coronary artery bypass surgery (11% vs 7%), length of stay (4.5 versus 4.4 days), and hospital costs ($ 103,247 vs $ 99,094). Notably, psoriasis patients had significantly lower in-hospital mortality (2.74% vs 4.93%). For the in-hospital mortality, the adjusted odds ratio was 0.70 (95% CI 0.56- 0.88) with a p-value of < 0.002.
Conclusion: Our study showed paradoxically lower overall mortality despite the higher prevalence of several comorbidities in AMI patients with psoriasis.
First Page
1327
DOI
10.1016/S0735-1097(23)01771-0
Publication Date
3-7-2023
Recommended Citation
Thwe EE, Mahesh M, Krishnamurthy M. The Psoriasis Mortality Paradox in Acute Myocardial Infarction: A Nationwide Inpatient Sample Analysis. Journal of the American College of Cardiology. 2023 Mar 7;81(8_Supplement):1327-.