Impact of Ventricular Arrhythmia on In-Hospital Outcomes in Patients with Sarcoidosis
Document Type
Article
Abstract
Background: Sarcoidosis (SD) is a systemic disease often associated with various arrhythmias, ventricular arrhythmia (VA: ventricular tachycardia and fibrillation) being the most common cause of death. We aimed to analyze the impact of VA on in-hospital outcomes in patients with SD.
Methods: National Inpatient Sample (NIS) 2014-2018 was used to find patients with primary diagnosis of VA with concurrent diagnosis of SD using appropriate ICD codes. SD patients were divided into two groups: with and without VA. Patients age <18 and history of acute or previous myocardial infarction were excluded. Baseline characteristics and in-hospital outcomes were compared. Variables with p<0.20 from univariate logistic regression were included in multivariate logistic regression to identify independent impact of VA on in-hospital outcomes. Results: Out of 25,805 patients with SD, 610 (2.4%) presented with primary diagnosis of VA. SD patients with VA were older (54 ± 11- vs-52.8 ± 13 years), more often male (56-vs-43%) and had higher burden of comorbidities (Table 1). Multivariate analysis showed VA as an independent predictor of higher in-hospital mortality (adjusted OR 2.47, CI 1.01-6.14, p<0.05), mean length of stay (LOS, Δ+5 days, p=0.002), mean total hospital cost (Δ +$ 90,571, p <0.001) and cardiogenic shock (adjusted OR 7.4, CI 2.74-19.8, p<0.001).
Conclusion: VA is an independent predictor of higher in-hospital mortality, mean length of stay, total hospital cost and cardiogenic shock in patients with SD.
First Page
127
DOI
10.1016/S0735-1097(22)01118-4
Publication Date
3-8-2022
Recommended Citation
Shah K, Taha I, Thyagaturu H, Modi VA, Krinock M, Pandya M, Cutitta C, Durkin MJ. IMPACT OF VENTRICULAR ARRHYTHMIA ON IN-HOSPITAL OUTCOMES IN PATIENT WITH SARCOIDOSIS. Journal of the American College of Cardiology. 2022 Mar 8;79(9_Supplement):127-.