In-hospital Mortality and Risk Factors in Critically Ill Adults with Hypertrophic Cardiomyopathy
Document Type
Article
Abstract
Background
Hypertrophic cardiomyopathy (HCM) is a common inherited cardiomyopathy with estimated prevalence of 0.2-0.5%. It has diverse phenotypic expression and clinical course. Contemporary management has substantially improved HCM outcomes. Impact of HCM on outcomes of critically ill patients admitted to intensive care units (ICU) has not been well studied.
Methods
Unmatched and propensity score matched adults with or without HCM were examined in a retrospective cohort of critically ill adults from the MIMIC-IV database. We compared mortality, morbidity, and length of stay in critically ill adults with or without HCM. Multivariable logistic regression was used to identify risk factors associated with in-hospital mortality in adults with HCM.
Results
Of 51,926 critically ill patients, 165 (0.32%) were also diagnosed with HCM. Compared with those without HCM, adults with HCM had higher BMI (29.6±8.7 vs 28.4±6.9 kg/m2, p=0.027), higher rate of heart failure (47.3% vs 22.4%, p
Conclusion
Presence of HCM does not impact in-hospital mortality in critically ill adults admitted to ICU. Use of circulatory support devices predicts worse in-hospital mortality among critically ill adults with HCM.
First Page
494
DOI
10.1016/S0735-1097(23)00938-5
Publication Date
3-7-2023
Recommended Citation
Ma Z, Shirani J. IN-HOSPITAL MORTALITY AND RISK FACTORS IN CRITICALLY ILL ADULTS WITH HYPERTROPHIC CARDIOMYOPATHY. Journal of the American College of Cardiology. 2023 Mar 7;81(8_Supplement):494-.