Takotsubo cardiomyopathy and psychiatric illness- insight from National Inpatient Sample (NIS) and National Re-admission Database (NRD) 2016 to 2018

Karthik Gonuguntla, Department of Cardiovascular Medicine, Heart and Vascular Institute, West Virginia University, West Virginia, USA
Harshith Thyagaturu, Department of Cardiovascular Medicine, Heart and Vascular Institute, West Virginia University, West Virginia, USA
Ayesha Shaik, Department of Cardiovascular Medicine, Hartford Hospital, Hartford, CT, USA
Nicholas Roma, Department of Internal Medicine, St. Luke's University Health Network, Bethlehem, PA, USA
Sittinun Thangjui, Department of Internal Medicine, Bassett Medical Center, NY, USA
Waleed Alruwaili, Department of Internal Medicine, West Virginia University, West Virginia, USA
Kunal N Patel, Department of Cardiovascular Medicine, Heart and Vascular Institute, West Virginia University, West Virginia, USA
Sameh Nassar, Department of Cardiovascular Medicine, Heart and Vascular Institute, West Virginia University, West Virginia, USA
Hardik Valand, Department of Internal Medicine, Trinity Health System, Steubenville, OH, USA
Mustafa Sajjad Cheema, CMH Lahore Medical College and Institute of Dentistry, Pakistan
Bobby Jain, Department of Psychiatry, Texas Tech University, TX, USA
Amna Ahmed, Allama Iqbal Medical College, Lahore, Pakistan
Sameer Raina, Stanford College of Medicine, Stanford, USA
Chobufo Muchi Ditah, Department of Cardiovascular Medicine, Heart and Vascular Institute, West Virginia University, West Virginia, USA
Yasar Sattar, Department of Cardiovascular Medicine, Heart and Vascular Institute, West Virginia University, West Virginia, USA

Document Type

Article

Abstract

Background: Emotional stress is a common precipitating cause of takotsubo cardiomyopathy (TC). Preexisting psychiatric disorder (PD) was linked to worsening outcomes in patients with TC1,2. However, there is limited data in literature to support this. This study aimed to determine the differences in outcomes in TC patients with and without PD.

Methods: We identified all patients with a diagnosis of TC using the National Inpatient Sample (NIS) and the National Readmission Database (NRD) data from 2016 to 2018. The patients were separated into TC with PD group and TC without PD group. Multiple variable logistic regression was then performed.

Results: Using NIS 2016-2018, we identified 23,220 patients with TC, and 43.11% had PD. The mean age was 66.73 ± 12.74 years, with 90.42% being female sex. The TC with PD group had a higher 30-readmission rate 1.25 (95% CI:1.06-1.47), Cardiogenic shock [aOR = 7.3 (95%CI 3.97-13.6), Mechanical ventilation [aOR = 4.2 (95%CI 2.4-7.5), Cardiac arrest [aOR = 2.6 (95%CI 1.1-6.3), than TC without PD group.

Conclusion: Psychiatric disorders were found in up to 43% of patients with TC. The concomitant PD in TC patients was not associated with increased mortality, AKI, but had higher rates of cardiogenic shock, use of mechanical ventilation and cardiac arrest. The TC group with PD was also associated with increased 30-day readmission, LOS and total charges compared to TC patients without PD.

First Page

102429

DOI

10.1016/j.cpcardiol.2024.102429

Publication Date

4-1-2024

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